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Dr. Aruni Bhatnagar

Dr. Bhatnagar is Professor of Medicine and Distinguished University Scholar at the University of Louisville. He is the Director of the Christina Lee Brown Envirome Institute and Co-Director of the American Heart Association Tobacco Regulation Center.  He is a leading expert on the mechanisms by which environmental exposures such as air pollution affect cardiovascular disease risk.  Dr. Bhatnagar’s initial work involved the purification and characterization of aldose reductase and its role in diabetic complications. To this end, he established the identity of this enzyme in several tissues and investigated its structural, kinetic, and inhibitory properties. His work has shown that increasing NO availability prevents aldose reductase activation and sorbitol accumulation in diabetic tissues.